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KMID : 0948320030030010023
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Konyang Medical Journal
2003 Volume.3 No. 1 p.23 ~ p.27
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The Expression of Cyclin-Dependent Kinase (CDK) Inhibitors, p27kip1 and p57kip2 in Mouse Testis During Post-natal Development
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Kim Sung-Tae
Lee Sung-Ki
Chung KH
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Abstract
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Regulation of cellular growth and differentiation through the activation of different cyclin-Cdks (cyclin-dependent kinases) at appropriate times is needed for normal development of testis. This study was to investigate the mRNA expression of CDK inhibitors, p27kip1과 and p57kip2 during the post-natal growth and differentiation of mouse testis, mRNA level of p27kip1과 was highly wxpressed in 1 week and 2 week old-testis, but decreased in 4 week and 8 week old-testis. Also, mRNA expression of p27kip1과 was higher in 1 week and 2 week old-testis than 4 week and 8 week old-testis. p27kip1과 was highly expressed about two fold than p57kip2 during post-natal testis development of mouse. These result suggest that the role of p27kip1 and p57kip2 might be required for the post-natal early development of mouse testis.
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KEYWORD
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mouse testis, p27kip1, p57kip2,
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